Patient-specific dosimetry in radionuclide therapy.
Identifieur interne : 001226 ( Main/Exploration ); précédent : 001225; suivant : 001227Patient-specific dosimetry in radionuclide therapy.
Auteurs : RBID : pubmed:21831867English descriptors
- KwdEn :
- Algorithms, Bone Neoplasms (radionuclide imaging), Bone Neoplasms (radiotherapy), Bone Neoplasms (secondary), Computer Simulation, Female, Humans, Indium Radioisotopes (therapeutic use), Individualized Medicine, Liver Neoplasms (pathology), Liver Neoplasms (radionuclide imaging), Liver Neoplasms (radiotherapy), Male, Monte Carlo Method, Octreotide (therapeutic use), Radioimmunotherapy, Radiometry, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Tomography, Emission-Computed, Single-Photon.
- MESH :
- chemical , therapeutic use : Indium Radioisotopes, Octreotide.
- pathology : Liver Neoplasms.
- radionuclide imaging : Bone Neoplasms, Liver Neoplasms.
- radiotherapy : Bone Neoplasms, Liver Neoplasms.
- secondary : Bone Neoplasms.
- Algorithms, Computer Simulation, Female, Humans, Individualized Medicine, Male, Monte Carlo Method, Radioimmunotherapy, Radiometry, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Tomography, Emission-Computed, Single-Photon.
Abstract
This study presents an attempt to compare individualised palliative treatment absorbed doses, by planar images data and Monte Carlo simulation, in two in vivo treatment cases, one of bone metastases and the other of liver lesions. Medical Internal Radiation Dose schema was employed to estimate the absorbed doses. Radiopharmaceutical volume distributions and absorbed doses in the lesions as well as in critical organs were also calculated by Monte Carlo simulation. Individualised planar data calculations remain the method of choice in internal dosimetry in nuclear medicine, but with the disadvantage of attenuation and scatter corrections lack and organ overlay. The overall error is about 7 % for planar data calculations compared with that using Monte Carlo simulation. Patient-specific three-dimensional dosimetric calculations using single-photon emission computed tomography with a parallel computed tomography study is proposed as an accurate internal dosimetry with the additional use of dose-volume histograms, which express dose distributions in cases with obvious inhomogeneity.
DOI: 10.1093/rpd/ncr329
PubMed: 21831867
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Medical Internal Radiation Dose schema was employed to estimate the absorbed doses. Radiopharmaceutical volume distributions and absorbed doses in the lesions as well as in critical organs were also calculated by Monte Carlo simulation. Individualised planar data calculations remain the method of choice in internal dosimetry in nuclear medicine, but with the disadvantage of attenuation and scatter corrections lack and organ overlay. The overall error is about 7 % for planar data calculations compared with that using Monte Carlo simulation. Patient-specific three-dimensional dosimetric calculations using single-photon emission computed tomography with a parallel computed tomography study is proposed as an accurate internal dosimetry with the additional use of dose-volume histograms, which express dose distributions in cases with obvious inhomogeneity.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21831867</PMID><DateCreated><Year>2011</Year><Month>10</Month><Day>31</Day></DateCreated><DateCompleted><Year>2012</Year><Month>02</Month><Day>28</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1742-3406</ISSN><JournalIssue CitedMedium="Internet"><Volume>147</Volume><Issue>1-2</Issue><PubDate><Year>2011</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Radiation protection dosimetry</Title><ISOAbbreviation>Radiat Prot Dosimetry</ISOAbbreviation></Journal><ArticleTitle>Patient-specific dosimetry in radionuclide therapy.</ArticleTitle><Pagination><MedlinePgn>258-63</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/rpd/ncr329</ELocationID><Abstract><AbstractText>This study presents an attempt to compare individualised palliative treatment absorbed doses, by planar images data and Monte Carlo simulation, in two in vivo treatment cases, one of bone metastases and the other of liver lesions. Medical Internal Radiation Dose schema was employed to estimate the absorbed doses. Radiopharmaceutical volume distributions and absorbed doses in the lesions as well as in critical organs were also calculated by Monte Carlo simulation. Individualised planar data calculations remain the method of choice in internal dosimetry in nuclear medicine, but with the disadvantage of attenuation and scatter corrections lack and organ overlay. The overall error is about 7 % for planar data calculations compared with that using Monte Carlo simulation. Patient-specific three-dimensional dosimetric calculations using single-photon emission computed tomography with a parallel computed tomography study is proposed as an accurate internal dosimetry with the additional use of dose-volume histograms, which express dose distributions in cases with obvious inhomogeneity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lyra</LastName><ForeName>Maria</ForeName><Initials>M</Initials><Affiliation>Radiation Physics Unit, A' Radiology Department, Kapodistrian University of Athens, 76 Vas Sophias Ave, Athens, Greece. mlyra@med.uoa.gr</Affiliation></Author><Author ValidYN="Y"><LastName>Lagopati</LastName><ForeName>Nefeli</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Charalambatou</LastName><ForeName>Paraskevi</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Vamvakas</LastName><ForeName>Ioannis</ForeName><Initials>I</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>08</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Radiat Prot Dosimetry</MedlineTA><NlmUniqueID>8109958</NlmUniqueID><ISSNLinking>0144-8420</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>RWM8CCW8GP</RegistryNumber><NameOfSubstance>Octreotide</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Algorithms</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Bone Neoplasms</DescriptorName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName><QualifierName MajorTopicYN="Y">radiotherapy</QualifierName><QualifierName MajorTopicYN="N">secondary</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Computer Simulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Individualized Medicine</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Liver Neoplasms</DescriptorName><QualifierName MajorTopicYN="N">pathology</QualifierName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName><QualifierName MajorTopicYN="Y">radiotherapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Monte Carlo Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Octreotide</DescriptorName><QualifierName MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Radioimmunotherapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Radiometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiotherapy Dosage</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Radiotherapy Planning, Computer-Assisted</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Tomography, Emission-Computed, Single-Photon</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2011</Year><Month>8</Month><Day>9</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>8</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>8</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>3</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">ncr329</ArticleId><ArticleId IdType="doi">10.1093/rpd/ncr329</ArticleId><ArticleId IdType="pubmed">21831867</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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